Technologies
AlivaMab® Mouse
Twelve of the top 25 pharma companies use Ablexis’ AlivaMab Mouse, the only transgenic animal with a differentiated design for diversity, speed, developability, and FTO.
To learn more about AlivaMab Mouse, visit www.ablexis.com.
AlivaMab Mouse Design Accelerates Progress from Discovery to Development
Innovative Design
- Peer-reviewed design for successful antibody discovery and FTO
Track Record
- Over 500 discovery projects since 2015
Outperformance
- Superior in direct testing versus in vitro display and other transgenic platforms
Versatility
- Hybrid, single B cell (plasma and memory), immune repertoire display
- Standard antibody, bispecifics, ADSs, CARs, etc.
Clinical Validation
- Multiple AlivaMab antibodies have entered clinical development since 2018
AMMPD Immunizations
Our powerful AMMPD immunization methodologies—which include innovative protein, cell, and DNA immunizations plus protocols that break immune tolerance—elicit very fast, robust, and diverse immune responses to even the most challenging targets in as little as two to six weeks.
AMMPD immunizations are used alone, in combination, and/or with tolerance-breaking strategies
Deep Mining of the Immune Repertoire by Display
Our advanced display-based workflows provide deeper interrogation of the immune repertoire using logic-gated panning to discover rare antibodies and deliver more sequences faster, without the need for affinity maturation.
Fit-for-Purpose Screening
Our high-throughput screening of both plasma and memory IgG+ B cell repertoires interrogates up to hundreds of thousands of hybridomas, which is an order of magnitude greater than some single B cell screening technologies and other hybridoma processes.
Bispecific Formats
We deliver bispecific antibodies that are designed for valency, affinity, and geometry to drive optimal activity. Further, they are stability engineered and tested for developability to ensure drug-like properties.
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